Comparison between tropisetron and granisetron in preventing postoperative nausea and vomiting for gynecologic laparoscopic surgery

Objective To compare the clinical effect of tropisetron and granisetron in preventing postoperative nausea and vomiting for gynecologic laparoscopic surgery.Methods Ninity patients,ASA class Ⅰ～Ⅱ,undergoing gynecologic laparoscopic surgery,were randomly divided into 3 groups,receiving an intravenous bolus of tropisetron 5 mg(group T,n=30),granisetron 3 mg(group G,n=30),or 0.9% NS 5 mL(group placebo,group NS,n=30) respectively at the end of the surgery.Results The incidences of postoperative nausea and vomiting in group T(20.0%,10.0%) and group G(20.0%,33.3%) were significantly lower than those in group NS(63.3%,60.0%)(P0.05) in postoperative 8 hours and 9～24 hours.The incidence of postoperative nausea and vomiting in group T was similar to that in group G in postoperative 8 hours(P0.05),but significantly lower than that in group G in postoperative 9～24 hours(10.0% vs 33.3%)(P0.05).Conclusion Tropisetron and granisetron can prevent postoperative nausea and vomiting of gynecologic laparoscopic surgery effectively,but the long-dated effects of tropisetron was better than that of granisetron.