Expression of P-ERK1/2 and Ki-67 and its significance in gastric mucosa pathological changes

Objective To explore the expression of P-ERK1/2 and Ki-67 in gastric mucosa lesions.Methods Expression of P-ERK1/2 and Ki-67 were examine in 124 cases of gastric mucosa biopsy.And there were 20 cases of the mild chronic atrophic gastritis,21 cases of the mild chronic atrophic gastritis with intestinal metaplasia and atypical hyperplasia,24 cases of moderate chronic atrophic gastritis,23 cases of moderate chronic atrophic gastritis with intestinal metaplasia and atypical hyperplasia and 36 cases of gastric carcinoma by immunohistochemical technique.Results The negative expression of P-ERK1/2 in mild chronic atrophic gastritis,mild chronic atrophic gastritis with intestinal metaplasia and atypical hyperplasia and moderate chronic atrophic gastritis.The expression of P-ERK1/2 were showed a trend of increasing in the moderate chronic atrophic gastritis with intestinal metaplasia and atypical hyperplasia and gastric cancer tissue.The differences were statistically significant between the groups(P 0.01).Negative expression of Ki-67 protein in mild chronic atrophic gastritis.The expression of Ki-67 was 66.67% and 79.17% in mild chronic atrophic gastritis with intestinal metaplasia and atypical hyperplasia and moderate chronic atrophic gastritis.The positive expression was 83.33% in gastric cancer tissue.The positive expression was 56.52% in moderate chronic atrophic gastritis with intestinal metaplasia and atypical hyperplasia.The differences were statistically significant between the groups(P 0.01).The expression of Ki-67 protein was positively correlated with that of P-ERK1/2 protein(P 0.01).Conclusion P-ERK1/2 protein involves in the malignant cell transformation to promote the occurrence of gastric cancer development.A significant positive relationship is observed between the expression of Ki-67 and P-ERK1/2.They contribute to the carcinogenesis and development gastric carcinoma in coordination.