2009•Journal of Rare and Uncommon DiseasesRequires access
Expression of bcl-2 protein in gastric mucosa of chronic atrophic gastritis
Lin Liu
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Abstract
Objective To This study was performed to see the expression status of bcl-2 protein in Chronic atrophic gastritis and investigate the relationship between precancerous lesion and cell apoptosis of gastric mucosa.Methods The expression of bcl-2 in 73 gastric mucosa samples with chronic gastritis was evaluated by s-p immunohistochemistry.Results Bcl-2 expression in glandular epithelium with chronic atrophic gastritis was remarkably higher than those with chronic superficial gastritis.Conclusion The over-expression of bcl-2 in chronic atrophic gastritis may be one of the important mechanisms in gastric glandular epithelium proliferation and apoptosis disequilibrium.