THE CLINICAL APPLIED VALUES OF MULTI-TUMOR MARKERS BY HD-2001A PROTEIN BIOCHIP TECHNOLOGY.

Objective:To study the clinical applied values of multi-tumor markers by protein biochip technology for tumor diagnosis.Methods:12 tumor biomarkers in samples from a known cancer group of 163 cancer patients were screened at different clinical stages,with 496 healthy people in control group,and case group including 163 cancer patients and 29 detected cancer patients with post-operation monitoring.We detected 223 tumor indes levels and the rate of conformation is 98.655%,compared with immuoassay method on auto-immuoassay analyzer(AXSYM,US).65 samples were provided with pathologic typing.Results:Six abnormal results beyond reference ranges were found in control group,which were finally diagnosed earlier period tumor by follow-up survey;133 results,which is 81.595 percent of 163 cancer patients,were detected abnormally by protein biochip.In addition,there were 26 patients with normal results,which were found in 29 detected cancer patients with post-operation monitoring,and only 3 results were abnormal.Conclusion:The higher sensitivity and specificity achieved by the combined use of the selected biomarkers especially show great potential for the early detection of the cancers.Mult-tumor markers by protein chip with may be applied to clinical tumor earlier screening,prognosis and effect.