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2002•Chinese Journal of Hospital PharmacyRequires access

Anti-fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats

Yin Yin

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Abstract

OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS Zhijizi may be useful for the treatment of hepatic fibrosis.

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OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS Zhijizi may be useful for the treatment of hepatic fibrosis.

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Available abstract

OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS Zhijizi may be useful for the treatment of hepatic fibrosis.

Key concepts: Carbon tetrachloride, Fibrosis, Hepatic fibrosis, Hyaluronic acid, Medicine, CCL4, Pathology, Liver fibrosis

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