Effects of Revascularization on Ventricular Remodeling and Heart Function in Patients with Acute Myocardial Infarction

Objective: To evaluate the effects of revascularization on ventricular remodeling and cardiac function in patients with acute myocardial infarction(AMI).Methods: Sixty-five AMI patients were divided into 2 groups: conventional therapy group(group A,n=20) and revascularization group(group B,n=45).Twenty healthy persons served as normal control(group C,n=20).The left ventricular end-diastolic dimension and volume(LVEDD and LVEDV),left ventricular end-systolic dimension and volume(LVESD and LVESV),left ventricular ejection fraction(LVEF),ratio of early and late diastolic blood flow peak velocity(VE/VA) of the 3 groups were determined by echocardiography at the 1st week,the 3rd month and the 6th month after AMI.Results: In groups A and B,LVEDD,LVEDV,LVESD and LVESV were higher,LVEF and VE/VA were lower in all time frames than those in group C(P0.05).The LVEDD,LVEDV and LVESV at the 6th month after AMI,and LVESD at the 3rd and the 6th month were lower,while the LVEF on the 6th month was higher in group B than those in group A.There was no significant difference of VE/VA between group A and group B in any time frame.Conclusions: AMI leads to ventricular remodeling and cardiac dysfunction.Revascularization may inhibit ventricular remodeling and improve left ventricular systolic function in AMI patients.