Recent clinical observation of tanshlnone IIA on prevention of left ventricular remodeling in cases with acute myocardial infarction

Objective: To study the clinical efficiency of tanshlnone ⅡA(TSN) on left ventricular remodeling in cases with acute myocardial infarction(AMI).Methods: Forty-six patients with AMI were randomly divided into treatment group(24 cases) and control group(22 cases).Routine treatments were given to the two groups,and 8-16 ml TSN was added in the treatment group by intravenous drip,once per day for 3 courses;14 days constituted one therapeutic course and the interval between the 2 courses was 2 days.Changes of left ventricular end diastolic volume index(LEDVI),left ventricular end systolic volume index(LESVI),left ventricular early diastolic engorge velocity/left ventricular end diastolic engorge velocity(E/A) and left ventricular ejection fraction(LVEF) were examined by ultrasound cardiogram on the 1 st day,in the 2 nd and 6 th weeks after admission.Results: In the comparison between the two groups,no significant differences were found in 2 weeks(all P0.05).LEDVI,LESVI,LVEF and E/A were improved,and the differences were significant between treatment group and control group in the 6 th weeks after treatment(all P0.05).Conclusion: TSN can reverse left ventricular remodeling in patients with AMI.