2002•Unpublished venueRequires access

Study on preparation and release of sustained-released nicotinylmethylamidi tablet

Ran Ren

Abstract

Objetive:To prepare sustained-release nicotinylmethylamidi(Ⅰ) tablets with HPMC as matrix material and evaluate its release properties. Methods:The sustained-release Ⅰ tablets were prepared with wet method. The effects of the amount and viscosity of HPMC and of the typse of bonding agents on drug release rate of the preparations in vitro were investigated by the orthogonal experimental design. Results: The release behavior of the sustained-release tablets was in accord with Higuchi equation .Types of bonding agents and the amount of HPMC had a significant effects on the release rate . Conclusion : The drug release of the sustained-release I tablets achieved the goal of the design.

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Key concepts: Chemistry, Viscosity, Chromatography, Immediate release, Controlled release, Drug, Matrix (chemical analysis), Materials science