Sedation Treatment of Propofol and Midazolam on Patients with Mechanical Ventilation in Intensive Care Unit

Objective To study the characteristics of quantity-effect,time-effect of propofol and midazolam on patients with mechanical ventilation in intensive care unit,as well as their influences on heart rate and blood pressure.Methods A clinical retrospective analysis being carried out in 50 cases,which have had mechanical ventilation and were sedated by propofol and midazolam.Propofol group and midazolam group had 25 cases respectively.Comparing the onset times to take effect and awakening times of the two groups,then summarizing the changes of heart rate and blood pressure of the two groups.Results The onset time to take effect and awakening time in propofol group are obviously less than that in midazolam group.In propofol group,after administered propofol for 10 minutes,heart rate,systolic arterial pressure and diastolic pressure of patients drop obviously,but no changes in midazolam group.Conclusion In sedation treatment of patients with mechanical ventilation in ICU,propofol need less onset time to take effect and awakening time,but propofol can result in dropping of heart rate and blood pressure,so we should optimize therapeutic regimen,which is based on the characteristics of sedatives and conditions of patients.