Clinical Observation of Combined Propofol and Midazolam for Sedation Therapy in ICU Mechanical Ventilation

Objective: To evaluate the effect of combined use of propofol and midazolam for sedation therapy in ICU mechanical ventilation Methods: Sixty-nine patients were randomly divided into two groups: study group(combined propofol and midazolam) with 35 cases and control group(midazolam group) with 34 cases.Heart rate,mean arterial pressure,respiration,oxygen saturation,drug onset time,wake time of drug withdrawal,the time of achieved satisfactory sedation and side effects were observed before and after the treatment.Results: There were significant differences between the two groups in signs of life before and after treatment(P0.05).Compared to the control group,there were shorter onset time and recovery time after treatment,as well as the time of achieved satisfactory sedation(P0.05).Two cases of nausea after drug withdrawal were observed in study group whereas 6 cases in control group.Blood pressure instability was observed in 6 patients in the study group and 5 cases in the control group.Conclusions: Combined use of propofol and midazolam which showed satisfied sedative effect with lower adverse reactions was safe and effective in sedation therapy in ICU mechanical ventilation.