Effects of Didang Qigui Decoction on blood plasma TXB_2 and platelet surface CD62_P/ CD63 in STZ-induced diabetes rats

Objective To observe therapeutic effects of Didang Qigui Decoction upon rats with diabetes that is induced by streptozoticin(STZ) by examining the levels of TXB2 in blood plasma and granule membrane glycoprotein(CD62P),lysosomal interal membrane protein(CD63) in platelet surface.Method 10 out of 70 female rats are chosen randomly as the blank control group(group A),then the rest are induced by STZ,waiting to develop diabetes rats which,afterwards,are divided randomly into model group(group B),glimepiride group(group C),maximum dosage group of the Decoction(group D),and Didang Qigui Decoction normal-dose group(group E).10 weeks intervention is given to all the above groups and the levels of TXB2 in blood plasma and CD62P,CD63 in platelet surface in each group are measured.Result After 10 weeks of intervention,comparing with group E,the levels of TXB2 in blood plasma and CD62P,CD63 in platelet surface were decreased in group B,group C and group D(P0.05).Conclusion It is possible that Didang Qigui Decoction restrains platelet activation and improves microcirculation by reducing blood plasma TXB2 and platelet surface CD62P,and CD63 content and further prevents or delays the occurrence and development of diabetic angiopathy.