Therapeutic effect of trimetazidine on patients with ischemic cardiomyopathy heart failure and significance of plasma level of brain natriuretic peptide

AIM To assess the 4-week therapeutic effect of cardiomyopathy(TMZ) on patients with ischemic heart failure and the changes of plasma level of brain natriuretic peptide(BNP).METHODS Sixty patients with ischemic cardiomyopathy heart failure were randomly divided into routine treatment group(30) and TMZ treatment group(30) and the patients were treated for 4 weeks.After treatment,the changes of BNP were observed between the two groups and the correlation between BNP and ultrasound values was explored.RESULTS No statistic difference in the BNP level was found between the two groups before treatment.After the 4-week treatment,the BNP level decreased in both groups,but the decrease was more marked in TMZ group,with significant difference between the two groups(P=0.042).The BNP level was significantly correlated to LVEF and LVEDD(r=0.481,0.311;P0.05).CONCLUSION TMZ has a positive effect on patients with ischemic cardiomyopathy heart failure,and the plasma BNP level,as follow-up index,has better sensitivity than echocardiography.BNP level is negatively correlated with LVEF and positively correlated with LVEDD.