Clinical study of the relationship between heart failure and plasma brain natriuretic peptide

Objective To investigate plasma brain natriuretic peptide(BNP) in heart failure patients,as well as the changes of the value of assessment of cardiac function.Methods Measured by Immune-fluorescence assay using 110 cases of patients with congestive heart failure(HF group) and 20 cases of healthy persons(control group) of plasma BNP concentration;use echocardiography measurement of left ventricular ejection fraction(LVEF).Results BNP in heart failure group was significantly higher than control group,the difference was statistically significant(P0.01),and the BNP level increased with the higher the group in NYHA classification of heart failure;BNP levels have a statistically significant difference(P0.01) in 4 different groups of cardiac function;Comparison with the pre-treatment,each group's concentration of BNP significantly reduced after one week treatment(P0.01);BNP level and LVEF was negatively correlated,and higher plasma BNP levels increase in mortality.Conclusion Monitoring BNP level can be used as the guidance indicators of diagnosis of heart failure,cardiac function assessment as well as the efficacy and prognosis.