Comparison of 3 intervals between mifepristone and misoprostol administration for the termination of early pregnancy

Objective To explore the effect on varying intervals of mifepristone combined with misoprostol for early pregnancy termination. Methods Totally 450 cases of early pregnancy were randomly divided into 3 groups. 150 cases in each group were orally administered 200 mg mifepristone and then followed with 0.6 mg misoprostol in 12, 24 and 48 hours later respectively. The eff icacy and adverse reactions of three groups were observed. Results The complete abortion rates in group 1, group 2 and group 3 were 82.00%, 91.33% and 92.00% respectively. The complete abortion rates in the experimental group 1 was lower than group 2 or 3(P0.01). There were no serious adverse reactions observed in the three groups. Conclusion Mifepristone 200 mg followed 24 hours later by misoprostol 0.6 mg orally is as effective for abortion as compared with a 48-hour dosing interval. It is an effective and safer approach for abortion.