Clinic Trial on Reduce Doses and New Method Mifepristone Plus Miseprostol as Termination Early Pregnancy

Objective:To find out the lowest doses and the best Method with Mifepristone plus Misoprostol for termination of early pregnancy. Methods:A randomized depart in 213 women requesting medical abortion at 36~84 day's gestation from clinic women were randomly divided into two Groups In Group I (n=106)women took Mifepristone 75 mg orally per day for 2 days(total dose 150 mg) and 48 hours later Misoprostol 0.6mg orally; Groups (n=107)Mifepristone 50 mg orally 12 hours later Misoprostol 0.2 mg orally for 2 days if the abortion has not occurred on 3th day in the morning continued to be taken Misoprostol 0.2 mg was q3h until the abortion happened. Results:The complete abortion rate of Group I to Group Ⅱ were 86.79%, 81.31% ( P 0.05) respectively. In incomplete abortion Curettage find out villus were 5.66%、6.54%( P 0.05)respectively. Doses of Mifepristone which GroupⅠ took 150mg and Misoprestol were 0.6mg ;The lowest were dose which Group Ⅱ took 50mg and 0.2mg respectively, the largest dose were 150mg and 1.0mg respectively. The average abortion time GroupⅠwas55o,Median was 54o15' respectively. GroupⅡ was 36o57',median was 36o,( P 0.01). Conclusion:Alternation used reducible dose of Mifepristone plus Misoprostol is effect for termination of early pregnancy and without difference as a routine treatment abortion time shorter than routine method .It is worth further study in the future.