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2014•Journal of Clinical Medicine in PracticeRequires access

Clinical significance of coagulation functional change in patients with acute pancreatitis

Yin Yuewe

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Abstract

Objective To investigate the change of coagulation function in patients with acute pancreatitis and its clinical significance for prognosis. Methods 240 patients with acute pancreatitis were divided in to moderate acute pancreatitis( MAP) group and severe acute pancreatitis( SAP)group( 169 and 71,respectively),another 180 subjects underwent health examination during same period were selected into control group. Results Levels of APTT,INR,PT,TT,FIB and D-dimer in SAP group were higher than those in MAP group and control group( P 0. 01); levels of AT?Ⅲ and PLT in SAP group were lower those in MAP and control group( P 0. 01). The level of PT,APPT,D-dimer were positively correlated with APACHE Ⅱ score in SAP group( P 0. 05),and level of AT?Ⅲand PLT were negatively correlated with APACHE Ⅱ score( P 0. 05). Conclusion Regular detection of coagulation functional change is potentially helpful for prognosis of patients with acute pancreatitis.

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Objective To investigate the change of coagulation function in patients with acute pancreatitis and its clinical significance for prognosis. Methods 240 patients with acute pancreatitis were divided in to moderate acute pancreatitis( MAP) group and severe acute pancreatitis( SAP)group( 169 and 71,respectively),another 180 subjects underwent health examination during same period were selected into control group. Results Levels of APTT,INR,PT,TT,FIB and D-dimer in SAP group were higher than those in MAP group and control group( P 0. 01); levels of AT?Ⅲ and PLT in SAP group were lower those in MAP and control group( P 0. 01). The level of PT,APPT,D-dimer were positively correlated with APACHE Ⅱ score in SAP group( P 0. 05),and level of AT?Ⅲand PLT were negatively correlated with APACHE Ⅱ score( P 0. 05). Conclusion Regular detection of coagulation functional change is potentially helpful for prognosis of patients with acute pancreatitis.

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Available abstract

Objective To investigate the change of coagulation function in patients with acute pancreatitis and its clinical significance for prognosis. Methods 240 patients with acute pancreatitis were divided in to moderate acute pancreatitis( MAP) group and severe acute pancreatitis( SAP)group( 169 and 71,respectively),another 180 subjects underwent health examination during same period were selected into control group. Results Levels of APTT,INR,PT,TT,FIB and D-dimer in SAP group were higher than those in MAP group and control group( P 0. 01); levels of AT?Ⅲ and PLT in SAP group were lower those in MAP and control group( P 0. 01). The level of PT,APPT,D-dimer were positively correlated with APACHE Ⅱ score in SAP group( P 0. 05),and level of AT?Ⅲand PLT were negatively correlated with APACHE Ⅱ score( P 0. 05). Conclusion Regular detection of coagulation functional change is potentially helpful for prognosis of patients with acute pancreatitis.

Key concepts: Medicine, Acute pancreatitis, Internal medicine, Pancreatitis, Clinical significance, Gastroenterology, Coagulation, D-dimer

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