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Experimental Study of the Ethanolic Estract from Potentilla Chinensis on Rat Hepatic Fibrosis Induced by Carbon Tetrachloride

Jua Yu-hai

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Abstract

Objective:To observe the curative effect of the ethanolic estract from Potentilla chinensis(PS) on rat hepatic fibrosis and to discuss it saction mechanism.Methods:The rat hepatic fibrosis model was made with 40% Carbon Tetrachloride(CCl4)0.5mL/100g intraperitoneal injection.PS treatment group was treated with PS5g/(kg·d)intragastric administration.The content Changes of hepatic function,blood hyaluronateacid(HA),superoxidedismutes(SOD) and malondialdehyde(MDA),and the hepatic microstructure changes were observed.Results:PS treatment group Compared with model control group,the alkalinephosphatase(ALP),MDA and HA lowered obviously(P0.01 and P0.05),the serum albumin(ALB) and SOD heightened obviously(P0.01),and the hepatic fibrosis degree lightened under lightmicroscope.Conclusion:PS has the action of protecting liver and delaying hepatic fibrosis formation,the mechanism maybe related with its santioxidation.

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Objective:To observe the curative effect of the ethanolic estract from Potentilla chinensis(PS) on rat hepatic fibrosis and to discuss it saction mechanism.Methods:The rat hepatic fibrosis model was made with 40% Carbon Tetrachloride(CCl4)0.5mL/100g intraperitoneal injection.PS treatment group was treated with PS5g/(kg·d)intragastric administration.The content Changes of hepatic function,blood hyaluronateacid(HA),superoxidedismutes(SOD) and malondialdehyde(MDA),and the hepatic microstructure changes were observed.Results:PS treatment group Compared with model control group,the alkalinephosphatase(ALP),MDA and HA lowered obviously(P0.01 and P0.05),the serum albumin(ALB) and SOD heightened obviously(P0.01),and the hepatic fibrosis degree lightened under lightmicroscope.Conclusion:PS has the action of protecting liver and delaying hepatic fibrosis formation,the mechanism maybe related with its santioxidation.

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Available abstract

Objective:To observe the curative effect of the ethanolic estract from Potentilla chinensis(PS) on rat hepatic fibrosis and to discuss it saction mechanism.Methods:The rat hepatic fibrosis model was made with 40% Carbon Tetrachloride(CCl4)0.5mL/100g intraperitoneal injection.PS treatment group was treated with PS5g/(kg·d)intragastric administration.The content Changes of hepatic function,blood hyaluronateacid(HA),superoxidedismutes(SOD) and malondialdehyde(MDA),and the hepatic microstructure changes were observed.Results:PS treatment group Compared with model control group,the alkalinephosphatase(ALP),MDA and HA lowered obviously(P0.01 and P0.05),the serum albumin(ALB) and SOD heightened obviously(P0.01),and the hepatic fibrosis degree lightened under lightmicroscope.Conclusion:PS has the action of protecting liver and delaying hepatic fibrosis formation,the mechanism maybe related with its santioxidation.

Key concepts: Carbon tetrachloride, Hepatic fibrosis, Medicine, Malondialdehyde, CCL4, Intraperitoneal injection, Fibrosis, Albumin

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Experimental Study of the Ethanolic Estract from Potentilla Chinensis on Rat Hepatic Fibrosis Induced by Carbon Tetrachloride — Research Paper | ScholarLens