Distribution and drug resistance of blood culture pathogens in ICU patients

OBJECTIVE To investigate the distribution and drug resistance of pathogens isolated from ICU blood culture,so as to provide reference for the clinical rational use of antibiotics.METHODS A total of 758 strains of pathogens isolated from ICU were collected,those pathogens were identified by VITEK32 system,the drug susceptibility testing was performed by K-B method.RESULTS A total of 758 pathogens were isolated,including 462(60.95%) strains gram-negative bacteria,247(32.59%) strains of gram-positive bacteria,and 49(6.46%) strains of fungi.The top three species of the gram-negative bacteria were Escherichia coli(174 strains,22.96%),Klebsiella pneumoniae(120 strains,15.83%),and Pseudomonas aeruginosa(60 strains,7.92%),the top three species of the gram-positive bacteria were coagulase-negative Staphylococci(151 strains,19.92%),Staphylococcus aureus(59 strains,7.78%),and Enterococci(21 strains,2.77%).The drug susceptibility testing showed that the gram-negative bacteria were most susceptible to imipenem,and the gram-positive bacteria were most susceptible to teicoplanin and vancomycin.CONCLUSION It is of great significance in the clinical treatment to use antibiotics on the basis of drug susceptibility testing and perform the monitoring of the drug susceptibility of the blood culture pathogens in ICU patients.