Study on protective action of cordyceps on immunological liver injury in mice model

Objective:To observe the protective action of cordyceps polysaccharides on immunological liver injury in mice model and its mechanism.Methods:An immunological liver injury in mice model was induced by administration of lipopolysaaccharide following injection of BCG vaccine into mice for 12 days.ALT,AST levels in serum,the activity of SOD and the concentration of MDA in liver homogenates were examined,TNF-α and IL-1 were assayed by ELISA and the liver pathology was observed.Results:The experiment showed that the cordyceps polysaccharides(125,250,500 mg/kg,ig)could reduce the rising ALT,AST levels in serum of mice with immunological liver injury induced by BCG+LPS,inhabit the rising MDA and enhance the activity of SOD,decrease obviously TNF-α,IL-1 in liver homogenates and the pathology cut section also showed significantly protective effect.Conclusion:Cordyceps polysaccharides has protective effect on immunological liver injury in mice.Its mechanism is possibly related to decrease TNF-α,IL-1 in liver homogenates and its equilibrium on cytokine production.