Effect of decreased blood pressure with Amlodipine by using Simvastatin

Objective To study the effect of decreased blood pressure with Amlodipine by using Simvastatin for longer period combination.Methods Ninety-eight patients who underwent the treatment by Amlodipine were reached mild essential hypertension.They were randomly divided into two groups.Forty-eight cases in the control group were treated with low fat、low salt diet and Amlodipine 5mg,qd or 5mg,bid.Fifty cases in simvastatin group were treated as well as control group combined with simvastatin 20mg qd,administered for twenty-four weeks.Two groups were compared with by ambulatory blood pressure monitoring before and after the treatment.Result After twenty-four weeks the treatment,the blood pressure in simvastatin group were decreased in 24hSBP、24hDBP、dSBP and dDBP,nSBP and nDBP,24h pp.Compararison of two groups showed signifficant difference (P0.01).simvastatin group were better than control group.Conclusion Amlodipine combined with simvastatin for long-term treatment be increased effect in decreased blood pressure.