A double blind comparative of antipsychotics combined with hydrochloride in treatment chronic schizophrenia

Objective To explore the efficacy of antipsychotics combined with hydrochloride in the treatment of chronic schizophrenia with negative symptoms.Methods Fifty-eight cases of chronic schizophrenia mainly with negative symptoms were randomly divided into combined groups(treated with antipsychotics and hydrochloride) and control group(treated with placebo).Twenty-nine cases respectively.The course of treatment was twelve weeks,The efficiency and side effects were evaluated by positive and negative symptoms scale(PANSS) treatment emergent symptoms scale(TESS) before and after treatments for 4,8,12 weeks.Results After 8 weeks treatments,the total scores and negative symptoms scale(TESS) before and after treatments PANSS signi?cantly decreased in the combined group than before treatments,and the increase of body weight of the combined group was also significantly lower than that of the control group.Conclusion Antipsychotics combined with hydrochloride should improve the negative symptoms of chroric schizophrenia.Two groups have no significant differences in side effects,and can restrain body weight increasing.