Blood Plasma ET,NO and Homocysteine in Patients with Pregnancy-induced Hypetension Syndrome

Objective To investigate the relation between the homocysteine and pregnancy-induced hypetension syndrome(PIH) as well as the mechanisms of blood plasma endothelin,nitrogen monoxidum in PIH.Methods 90 PIH women included 36 gestational hypertension,30 mild preeclampsias,and 24 severe preeclampsias,and another 40 normal late-term pregnant women as controls were recruited in this study.The plasma Hcy were determined by fluorescence polarization immunoassay and plasma endothelin,nitrogen monoxidum were determined by radio immunoassay and chemical method,respectively.Results The plasma Hcy and ET levels in PIH was significantly higher those in controls as well as the plasma NO was significantly lower in PIH than that in control group,especially in the those with preeclampsia.The plasma Hcy level had positive correlation with plasma ET level and had negative correlation with plasma NO level in PIH.Conclusion The Hcy in plasma which resulted in the increase of plasma ET and NO level can be regarded as the important mechanisms of inducing the development of PIH.