Analysis of the variation and clinical value of serum homocysteine and cystatin C in pregnancy induced hypertension syndrome

Objective To investigate the changes and clinical value of serum homocysteine(Hcy)and cystatin C(CysC)in pregnancy induced hypertension(PIH).Methods The clinical data of 118 patients with PIH in our hospital from October 2010 to June 2014 were retrospectively analyzed,including 32 cases of mild PIH,49 cases of moderate PIH and 37 cases of severe PIH.In addition,55 normal pregnant women during the same period were selected as the control group.The enzymatic cycling method and the colloidal gold immune turbidimetry were adopted to detect the serum Hcy and CysC levels and the detecting results were compared between the two groups.Results The systolic blood pressure in the control group,mild PIH group,moderate PIH group and severe PIH group were(122.38±10.29),(154.32±12.11),(177.19±14.29),(188.37±15.49)mm Hg respectively,the differences among the above groups were statistically significant(P0.05);the levels of serum Hcy and CysC in the PIH groups were all significantly higher than those in the control group(P0.05),moreover which in the severe PIH group were significantly higher than those in the mild and moderate PIH groups,the differences were statistically significant(P0.05);the positive correlation existed between the levels of Hcy and CysC with blood pressure(r0,P0.05).Conclusion The serum Hcy and CysC levels are positively correlated with the systolic blood pressure,which has the higher value for the clinical diagnosis of PIH.