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2008•Journal of Medical Science Yanbian UniversityRequires access

Protective effects of the Legan compound on cultured hepatocytes of rats in vitro

Jin Dong-zhu

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Abstract

OBJECTIVE To investigate the protective effects of the Legan compound on CCl_4-intoxicated primary cultured hepatocytes of rats in vitro.METHODS The hepatocytes of rats were cultured in vitro, and made hepatocytes injury models by CCl_4,and the effects of the Legan compound for the activity of SDH,ACPase,G-6-Pase activeties and amount of hepatic glycogen were observed.RESULTS The Legan compound increased the activity of SDH,G-6-Pase and the amount of hepatic glycogen,and restrain the activety of ACPase.CONCLUSION The Legan compound has protective effects on CCl_4-induced injury of primary cultured hepatocytes of rats in vitro.

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OBJECTIVE To investigate the protective effects of the Legan compound on CCl_4-intoxicated primary cultured hepatocytes of rats in vitro.METHODS The hepatocytes of rats were cultured in vitro, and made hepatocytes injury models by CCl_4,and the effects of the Legan compound for the activity of SDH,ACPase,G-6-Pase activeties and amount of hepatic glycogen were observed.RESULTS The Legan compound increased the activity of SDH,G-6-Pase and the amount of hepatic glycogen,and restrain the activety of ACPase.CONCLUSION The Legan compound has protective effects on CCl_4-induced injury of primary cultured hepatocytes of rats in vitro.

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Available abstract

OBJECTIVE To investigate the protective effects of the Legan compound on CCl_4-intoxicated primary cultured hepatocytes of rats in vitro.METHODS The hepatocytes of rats were cultured in vitro, and made hepatocytes injury models by CCl_4,and the effects of the Legan compound for the activity of SDH,ACPase,G-6-Pase activeties and amount of hepatic glycogen were observed.RESULTS The Legan compound increased the activity of SDH,G-6-Pase and the amount of hepatic glycogen,and restrain the activety of ACPase.CONCLUSION The Legan compound has protective effects on CCl_4-induced injury of primary cultured hepatocytes of rats in vitro.

Key concepts: In vitro, Hepatocyte, Glycogen, Chemistry, Pharmacology, Biochemistry, Biology

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