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2012•Chinese Journal of Modern Drug ApplicationRequires access

A comparative study of cognitive therapy plus Paroxetine in the treatment of depression in epilepsy

Huang Xin-rong

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Abstract

Objective To investigate the effect of cognitive therapy plus Paroxetine in the treatment of depression in epilepsy.Methods The 96 depression in epilepsy were randomly divided into treatment group and control group,the treatment group were given Paroxetine plus cognitive therapy,the control group were given Paroxetine during treatment of 12 weeks.The effect was assessed by Hamailton Depression Rating Scale(HAMD).The safety was assessed by treatment emergent symptoms scale(TESS).Results The score of HAMD was reduced significantly after 4 weeks and 12 weeks in two groups(P0.01),with markedly lower score of HAMD in treatment group in 4 weeks and 12 weeks when compared to that in control group(P0.05、P0.01).The effect in the treatment group was significantly better than that of the control group.The scres of TESS was no significant differences between two groups after 4 weeks and 12 weeks.Conclusion Cognitive therapy plus paroxetine has better effect in treatment of depression in epilepsy.

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What this paper is about

Objective To investigate the effect of cognitive therapy plus Paroxetine in the treatment of depression in epilepsy.Methods The 96 depression in epilepsy were randomly divided into treatment group and control group,the treatment group were given Paroxetine plus cognitive therapy,the control group were given Paroxetine during treatment of 12 weeks.The effect was assessed by Hamailton Depression Rating Scale(HAMD).The safety was assessed by treatment emergent symptoms scale(TESS).Results The score of HAMD was reduced significantly after 4 weeks and 12 weeks in two groups(P0.01),with markedly lower score of HAMD in treatment group in 4 weeks and 12 weeks when compared to that in control group(P0.05、P0.01).The effect in the treatment group was significantly better than that of the control group.The scres of TESS was no significant differences between two groups after 4 weeks and 12 weeks.Conclusion Cognitive therapy plus paroxetine has better effect in treatment of depression in epilepsy.

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Available abstract

Objective To investigate the effect of cognitive therapy plus Paroxetine in the treatment of depression in epilepsy.Methods The 96 depression in epilepsy were randomly divided into treatment group and control group,the treatment group were given Paroxetine plus cognitive therapy,the control group were given Paroxetine during treatment of 12 weeks.The effect was assessed by Hamailton Depression Rating Scale(HAMD).The safety was assessed by treatment emergent symptoms scale(TESS).Results The score of HAMD was reduced significantly after 4 weeks and 12 weeks in two groups(P0.01),with markedly lower score of HAMD in treatment group in 4 weeks and 12 weeks when compared to that in control group(P0.05、P0.01).The effect in the treatment group was significantly better than that of the control group.The scres of TESS was no significant differences between two groups after 4 weeks and 12 weeks.Conclusion Cognitive therapy plus paroxetine has better effect in treatment of depression in epilepsy.

Key concepts: Paroxetine, Hamd, Depression (economics), Hamilton depression scale, Rating scale, Epilepsy, Medicine, Treatment and control groups

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