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2008•The Chinese Journal of Modern Applied PharmacyRequires access

The Effect of Paroxetine Plus Psychotherapy in the Treatment of Post-stroke Depression

FU Guo-qing

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Abstract

OBJECTIVE To study the effect of paroxetine plus psychotherapy in the treatment of post-stroke depression.METHODS 106 patients with post-stroke depression were randomly divided into treatment group and control group,the treatment group were given paroxetine plus psychotherapy,the control group were given paroxetine only for 8 weeks.The efficacy was assessed by Hamailton Depression Rating Scale(HAMD)and Barthel Index(BI).RESULTS The score of HAMD of the treatment group was significantly lower after 8 weeks than that of the control group,and the score of BI of the treatment group was significantly higher after 8 weeks than that of the control group(P0.01).CONCLUSION Paroxetine plus psychotherapy has better effect in treatment of post-stroke depression.

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OBJECTIVE To study the effect of paroxetine plus psychotherapy in the treatment of post-stroke depression.METHODS 106 patients with post-stroke depression were randomly divided into treatment group and control group,the treatment group were given paroxetine plus psychotherapy,the control group were given paroxetine only for 8 weeks.The efficacy was assessed by Hamailton Depression Rating Scale(HAMD)and Barthel Index(BI).RESULTS The score of HAMD of the treatment group was significantly lower after 8 weeks than that of the control group,and the score of BI of the treatment group was significantly higher after 8 weeks than that of the control group(P0.01).CONCLUSION Paroxetine plus psychotherapy has better effect in treatment of post-stroke depression.

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Available abstract

OBJECTIVE To study the effect of paroxetine plus psychotherapy in the treatment of post-stroke depression.METHODS 106 patients with post-stroke depression were randomly divided into treatment group and control group,the treatment group were given paroxetine plus psychotherapy,the control group were given paroxetine only for 8 weeks.The efficacy was assessed by Hamailton Depression Rating Scale(HAMD)and Barthel Index(BI).RESULTS The score of HAMD of the treatment group was significantly lower after 8 weeks than that of the control group,and the score of BI of the treatment group was significantly higher after 8 weeks than that of the control group(P0.01).CONCLUSION Paroxetine plus psychotherapy has better effect in treatment of post-stroke depression.

Key concepts: Paroxetine, Hamd, Post-stroke depression, Depression (economics), Hamilton depression scale, Rating scale, Treatment and control groups, Psychology

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