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An Experimental Study on Effects of HAS Against Hepatic Fibrosis in Rats

Rusong Zhang

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Abstract

Objective:To research the effects and mechanism of HAS from Hydrozotyle sibthorpioides Lam.on rats with hepatic fibrosis.Methods:Experimental fibrosis model was copied by intracutaneous injection of swine serum,setting up normal group,model group,Tetrandrine group and HAS treated group with the dose of 1.5,0.5,0.1g/kg.The effects of HAS on the levels of ALT,AST,Alb,TB,Hyp were tested and the pathological chages of hepatic tissue were observed.Results:The levels of ALT,AST in serum and Hyp in liver decreased obviously compared with model group and the pathological chages releaved in all HAS treated groups,significantly in the 1.5g/kg group(P0.01).Conclusion:HAS has theraputic effect on imnune liver fibrosis which shows a dose-dependent manner.

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Objective:To research the effects and mechanism of HAS from Hydrozotyle sibthorpioides Lam.on rats with hepatic fibrosis.Methods:Experimental fibrosis model was copied by intracutaneous injection of swine serum,setting up normal group,model group,Tetrandrine group and HAS treated group with the dose of 1.5,0.5,0.1g/kg.The effects of HAS on the levels of ALT,AST,Alb,TB,Hyp were tested and the pathological chages of hepatic tissue were observed.Results:The levels of ALT,AST in serum and Hyp in liver decreased obviously compared with model group and the pathological chages releaved in all HAS treated groups,significantly in the 1.5g/kg group(P0.01).Conclusion:HAS has theraputic effect on imnune liver fibrosis which shows a dose-dependent manner.

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Available abstract

Objective:To research the effects and mechanism of HAS from Hydrozotyle sibthorpioides Lam.on rats with hepatic fibrosis.Methods:Experimental fibrosis model was copied by intracutaneous injection of swine serum,setting up normal group,model group,Tetrandrine group and HAS treated group with the dose of 1.5,0.5,0.1g/kg.The effects of HAS on the levels of ALT,AST,Alb,TB,Hyp were tested and the pathological chages of hepatic tissue were observed.Results:The levels of ALT,AST in serum and Hyp in liver decreased obviously compared with model group and the pathological chages releaved in all HAS treated groups,significantly in the 1.5g/kg group(P0.01).Conclusion:HAS has theraputic effect on imnune liver fibrosis which shows a dose-dependent manner.

Key concepts: Tetrandrine, Hepatic fibrosis, Pathological, Medicine, Liver fibrosis, Normal group, Internal medicine, Fibrosis

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