Effects of FuGanNing on Serum HYP SOD and MDA in Rats with Immune Hepatic Fibrosis

Objective:To study the therapeutic effect and mechanism of FuGanNing on rat with immune hepatic fibrosis induced by porcine serum injection.Methods: The immune hepatic fibrosis model was induced intraperitoneal injection of porcine serum. Seventy Wistar rats were randomly divided into six groups: normal group, model group, colchincines group, low, middle and high dose FuGanNing groups. After 6 weeks, all rats were given medicine via gastrogavage respectively. At the end of 10th weeks, all rats were sacrificed. The serum levels of hydroxyproline (HYP) content, malondial dehyde (MDA) content, superoxide disumutase (SOD) activity of liver tissue were measured respectively. The histological changes of liver tissue were observed with optic microscope.Results: Compared with normal group, the content HYP of the model group were significantly increased (P0.01). The levels of HYP of high and middle dose group were lower than that of model group, namely, HYP (P0.01). The levels of HYP of low dose group were lower than that of model group (P0.05). The levels of HYP of colchincines group were lower than that of model group, namely HYP (P0.01). Compared with model group, the MDA content of FuGanNing groups were reduced and the SOD activity of FuGanNing groups were increased. Pathological observation: Compared with the normal group, the model group had shown typical hepatic fibrosis. The degree of hepatic fibrosis of all treatment groups was lower than that of the model group, especially that of high dose group (P0.01).Conclusion: FuGanNing is very efficient in treating hepatic fibrosis. Eliminating Oxygen Radicals, suppressing lipid peroxideand and decreasing the levels of ECM may be its therapeutic mechanism.