Study on the determination of dissolution rates of Niuhuang Jiedu tablets

OBJECTIVE To establish a method for determining the dissolution rates of baicalin in Niuhuang Jiedu tablets and provide a method for evaluating and controlling the drug quality.METHODS Dissolution experiments were established.According to Chinese pharmacopoeia(2000)dissolution method and using 1% acohol solution as the dissolution medium.HPLC was adopted to determine baicalin. The accumulative dissolution of Niuhuang Jiedu tablets was calculated.The data of drug dissolution rate was treated with Microsoft Excel .The parameters(T_(d),m)obtained from these samples were processed for correlation test. RESULTS The average recovery was 102.5% with RSD of 1.60%(n=9).The linear range was 1-10 μgml~(-1) (r=0.9994).The dissolution of the drug was less affected by rotation rate,but more affected by the concentration of solvent. There were significant differences in dissolution parameters between the tested tablets(P0.01).CONCLUSION The established method shows to be sensitive,accurate and rapid for the determination of the dissolution rates of baicalin in Niuhuang Jiedu tablets. It is suitable for the quality control of the preparation.