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Studies on Preparation of Baicalin Dispersible Tablets and Its Determination of Dissolution Rate

Junhong Liu

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Abstract

Objective:To study the preparation of baicalin dispersible tablet and determination of its dissolution rate.Methods:The excipients and baicalin were blended into a stable homogeneous mixture by using trituration.The tablets was prepared by using direct compression process and the dissolution of the tablets was determined by high performance liquid chromatography(HPLC) method.Results:The baicalin was provided with a good linear range of 10~100μ/mL;the average recovery was 100.60% and RSD of 1.96%;the cumulative dissolution percentage exceeded 75% in 120 min.Conclusion:The preparation method is simple and easy to operate.The dissolution result was stable and reliable.

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What this paper is about

Objective:To study the preparation of baicalin dispersible tablet and determination of its dissolution rate.Methods:The excipients and baicalin were blended into a stable homogeneous mixture by using trituration.The tablets was prepared by using direct compression process and the dissolution of the tablets was determined by high performance liquid chromatography(HPLC) method.Results:The baicalin was provided with a good linear range of 10~100μ/mL;the average recovery was 100.60% and RSD of 1.96%;the cumulative dissolution percentage exceeded 75% in 120 min.Conclusion:The preparation method is simple and easy to operate.The dissolution result was stable and reliable.

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Available abstract

Objective:To study the preparation of baicalin dispersible tablet and determination of its dissolution rate.Methods:The excipients and baicalin were blended into a stable homogeneous mixture by using trituration.The tablets was prepared by using direct compression process and the dissolution of the tablets was determined by high performance liquid chromatography(HPLC) method.Results:The baicalin was provided with a good linear range of 10~100μ/mL;the average recovery was 100.60% and RSD of 1.96%;the cumulative dissolution percentage exceeded 75% in 120 min.Conclusion:The preparation method is simple and easy to operate.The dissolution result was stable and reliable.

Key concepts: Baicalin, Dissolution, Chromatography, High-performance liquid chromatography, Chemistry, Dissolution testing, Homogeneous, Materials science

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