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2006•Chinese Journal of Hospital PharmacyRequires access

Effect of azone and menthol on the in vitro percutaneous permeability of the Jiangchi gel in vitro

Yi Zhou

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Abstract

OBJECTIVE To study the effect of the concentration of azone and menthol on the percutaneous permeability of the Jiangchi gel in vitro.METHODS Isolated rat skin was taken as the permeable barrier by using a modified Franz absorbing-cell device.The content of paeoniflorin in the modified Franz absorbing-cell device was dertermined by HPLC,and the cumulation of paeoniflorin permeated through the rat skin was calculated.RESULTS Azone and menthol were found to increase the penetration of paeoniflorin in the gel,and the order of penetration enhancing effect was 9%7%5%3%1% in azone and 10%7%13%4%1% in menthol.CONCLUSION The study shows the relation of quantity-effect of azone and menthol on increasing the penetration of paeoniflorin in the gel.

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OBJECTIVE To study the effect of the concentration of azone and menthol on the percutaneous permeability of the Jiangchi gel in vitro.METHODS Isolated rat skin was taken as the permeable barrier by using a modified Franz absorbing-cell device.The content of paeoniflorin in the modified Franz absorbing-cell device was dertermined by HPLC,and the cumulation of paeoniflorin permeated through the rat skin was calculated.RESULTS Azone and menthol were found to increase the penetration of paeoniflorin in the gel,and the order of penetration enhancing effect was 9%7%5%3%1% in azone and 10%7%13%4%1% in menthol.CONCLUSION The study shows the relation of quantity-effect of azone and menthol on increasing the penetration of paeoniflorin in the gel.

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Available abstract

OBJECTIVE To study the effect of the concentration of azone and menthol on the percutaneous permeability of the Jiangchi gel in vitro.METHODS Isolated rat skin was taken as the permeable barrier by using a modified Franz absorbing-cell device.The content of paeoniflorin in the modified Franz absorbing-cell device was dertermined by HPLC,and the cumulation of paeoniflorin permeated through the rat skin was calculated.RESULTS Azone and menthol were found to increase the penetration of paeoniflorin in the gel,and the order of penetration enhancing effect was 9%7%5%3%1% in azone and 10%7%13%4%1% in menthol.CONCLUSION The study shows the relation of quantity-effect of azone and menthol on increasing the penetration of paeoniflorin in the gel.

Key concepts: Azone, Paeoniflorin, Menthol, Chemistry, Penetration (warfare), Chromatography, Permeability (electromagnetism), In vitro

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Effect of azone and menthol on the in vitro percutaneous permeability of the Jiangchi gel in vitro — Research Paper | ScholarLens