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2003•Chinese Journal of MisdiagnosticsRequires access

Relationship between Sera TNFalevel and Insulin Resistance in Patients with Type 2 Diabetes

Xing-qing Huang

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Abstract

Objective:To explore the relationship between sera TNFalevels and insulin resistance in patients with type 2 diabetes. Methods: 23 healthy persons (control group) ,28 cases of type-2 diabetes mellitus were selected to determine fasting blood glucose, fasting blood-insulin and serum TNF-a by oxidase method, RIA and ELISA. Insulin sensitivity index(ISI) was calculated. Results:TNF-a levels were significantly higher while ISI lower in DM group than those in control group(P0. 01). Conclusions. In type 2 diabetes mellitus the level of TNF-a increased and it was negatively correlated to ISI, which plays an important role in the development of the disease.

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Objective:To explore the relationship between sera TNFalevels and insulin resistance in patients with type 2 diabetes. Methods: 23 healthy persons (control group) ,28 cases of type-2 diabetes mellitus were selected to determine fasting blood glucose, fasting blood-insulin and serum TNF-a by oxidase method, RIA and ELISA. Insulin sensitivity index(ISI) was calculated. Results:TNF-a levels were significantly higher while ISI lower in DM group than those in control group(P0. 01). Conclusions. In type 2 diabetes mellitus the level of TNF-a increased and it was negatively correlated to ISI, which plays an important role in the development of the disease.

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Available abstract

Objective:To explore the relationship between sera TNFalevels and insulin resistance in patients with type 2 diabetes. Methods: 23 healthy persons (control group) ,28 cases of type-2 diabetes mellitus were selected to determine fasting blood glucose, fasting blood-insulin and serum TNF-a by oxidase method, RIA and ELISA. Insulin sensitivity index(ISI) was calculated. Results:TNF-a levels were significantly higher while ISI lower in DM group than those in control group(P0. 01). Conclusions. In type 2 diabetes mellitus the level of TNF-a increased and it was negatively correlated to ISI, which plays an important role in the development of the disease.

Key concepts: Medicine, Insulin resistance, Internal medicine, Diabetes mellitus, Endocrinology, Type 2 Diabetes Mellitus, Insulin, Type 2 diabetes

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