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The relationship between tumor necrosis factor-α and insulin resistance in patients with type 2 diabetes

Zeng Shun

Abstract

Objective:To study the relationship between tumor necrosis factor-α(TNF-α)and insulin resistance in the serum of type2diabetes.Methods:The fasting blood glucose,fasting blood-insulin and serum TNF-αin23healthy persons(control group)and22type2diˉabetes patients were respectively measured by oxidase method,RIA and ELISA,and compared between two groups.The insulin sensitivity index(ISI)was calcuated.Results:The level of TNF-αin type2diabetes group was significantly higher than that in control group(P0.01),but ISI was lower(P0.01).Conclusion:In type2diabetes patients,the increase of TNF-αlevel is related to insulin resistance,which plays an imˉportant role in the occurrence and development of this disease.

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Key concepts: Medicine, Insulin resistance, Internal medicine, Tumor necrosis factor alpha, Endocrinology, Tumor necrosis factor α, Type 2 diabetes, Insulin