Comparison study of venlafaxine combined with quetiapine versus single venlafaxme in treatment of somatoform disorders

AIM To study the clinical effects and safety of venlafaxine combined with quetiapine in treatment of somatoform disorders.METHODS Totally 167 patients were randomly assigned into study group (venlafaxine(145±25) mg?d~(-1) combined with quetiapine(255±12) mg?d~(-1),n = 84) and control group (venlafaxine(155±37) mg?d~(-1),n = 83),treated for 8 weeks.Before the treatment and at the ends of wk 2, wk8 of treatment,the clinical effects and safety were assessed with SCL-90,HAMD,and TESS.RESULTS The study group completed 82 patients with 2 patients dropped,and the control group completed 82 patients with 1 patient dropped.At the end of wk 2 of the treatment,the scores of SCL-90 somatization and HAMD of the two groups were lower than those before the treatment(P 0.05,P 0.01).At the end of wk 8,there were significant differences in the scores of SCL-90 somatization and HAMD between the two groups(P 0.01).The effective rates of the study group and control group were 83%and 59%respectively,with a significant difference(P 0.05).There was no significant difference between the TESS socres of the two groups(P 0.05).Adverse reactions of the two groups were milder,and most of those occurred in the initial stage of the treatment and gradually remitted via expectant treatment.CONCLUSION The efficacy of venlafaxine combined with quetiapine is better than that of single venlafaxine in the treatment of somatoform disorders,and the safety is equivalent.