Comparative Study of Venlafaxine Combined with Quetiapine in Treatment of Refractory Depression

[Objective]To explore the safety and efficacy of venlafaxine combined with quetiapine in treatment of refractory depression.[Methods]A total of 92 patients with refractory depression were randomly divided into 2 groups,the study group was treated with venlafaxine and quetiapine,and the control group used venlafaxine for treatment.All subjects were assessed with HAMD and CGI,Asberg Rating Scale for Side Effects was adopted to evaluate adverse effects of the 2 groups of drugs at the ends of 2nd,4th,8th,12th weeks.[Results]According to HAMD score,the rates of decreased scores at the end of 8th week were(31.85±12.78)in study group and(19.00±11.88)in control group.That at the end of 12th week was(48.46±20.75)and(29.54±16.85)respectively;the differences between 2 groups were significant(P0.05).At the end of 8th week,the scores of CGI were(2.31±0.95)in study group,(3.15±1.06)in control group and at the end of 12th week were(2.00±1.00)and(2.92±1.19)respectively,there were significant differences between 2 groups(P0.05).No significant difference of side effects were found between 2 groups(P0.05).[Conclusion] Venlafaxine combined with quetiapine is effective in the treatment of refractory depression,without significant increase in adverse reaction.