Analysis of detection rate and drug resistance of ESBLs-producing K.pneumoniae strains from 2004 to 2006

Objective To analyze and compare the detection rate and drug resistance of extended spectrum β lactamases(ESBLs)-producing K.pneumoniae strains in our hospital from 2004 to 2006.Methods VITEK-AMS microbial autoanalyzer was applied to identifying strain species and drug susceptibility test,while ESBLs test was carried out for the isolated K.pneunoniae strains.Results The detection rates for ESBLs-producing K.pneumoniae were 20.5%,34.1% and 41.9% in 2004,2005 and 2006 respectively.Especially for Department of Newborns,the detection rate kept the highest over the three years.Imipenem-resistant strains weren't detected.ESBLs-producing strains were steeply resistant to the third generation cephalosporins and bactrim,much higher than non-ESBLs producing strains.Conclusion ESBLs-producing K.pneumoniae shows a tendency of increasing year by year.The cephem antibiotics should be used cautiously so as to reduce the heneration of ESBLs-producing K.pneumoniae strains and to prevent outbreak and prevalence of ESBLs producing K.pneumoniae infection.