Correlation analysis of N-terminal brain natriuretic peptide,brain natriuretic peptide and ST2 with heart failure severity

Objective To understand the correlation of N-terminal brain natriuretic peptide(NT-pro-BNP),brain natriuretic peptide(BNP) and ST2 with severity of heart failure,and thus to investigate the diagnostic values of these indicators.Methods 354 cases of heart failure admitted to our hospital from January 2009 to July 2012 were classified according to the New York Heart Association(NYHA) heart function standard.All patients were asked in detail about medical history and completed NT-pro-BNP,BNP and ST2 check on the basis of routine examination after admission.Results Compared with control group,NT-pro-BNP,BNP and ST2 blood concentration levels were significantly increased in the heart failure group;There were significant differences in NT-pro-BNP,BNP and ST2 blood concentration levels between different classification groups(P 0.05,P 0.01);Spearman correlation analysis showed that NT-pro-BNP,BNP and ST2 blood concentration levels increased with the severity of heart failure;ROC curve showed that the correlation coefficients for NT-pro-BNP,BNP and ST2 were 0.970,0.785 and 0.980 respectively.Conclusion NT-pro-BNP,BNP and ST2 indicators are positively related to the severity of heart failure,thus it can be used for the assessment of the severity of heart failure and also for the diagnosis of heart failure.Among the three indicators,NT-pro-BNP is the most sensitive markers in the diagnosis of heart failure.