Correlation of brain natriuretic peptide level with cardiac function

Objective To explore the correlation of brain natriuretic peptide level with cardiac function in order to elucidate the importance of measurement of BNP in heart failure(HF). Methods Fifty-six patients with heart failure and 52 patients controls without HF were enrolled in the study and samples of BNP,blood glucose and lipid were obtained on admission day.The plasma levels of BNP were examined by ELISA.The correlation of plasma levels of BNP with cardiac function were analyzed by SPSS for windows V10.0,statistical package.Results The plasma levels of BNP were gradually elevated with the severity of HF.The change of BNP level was negatively correlated with LVEF(P0.01).Conclusion Plasma BNP levels increase in patients with CHF,and markedly increased according to the severity of heart failure classified by NYHA classification.