Sichuan Provincial of antimicrobial Resistant Investigation Net 2011 annual report:Bacterial drug resistance surveillance in East Sichuan

Investigate the distribution and the drug resistance of the pathogenic bacteria isolates from clinical specimen in East Sichuan and provide the reasonable usage of antibiotics in clinical treatment. Using French Bio-Merieux semi-automatic API,automatic microbiology analysis system VITEK or manual methods for strain identification and drug sensitive test to CLSI 2010 edition as standard,with WHO NET5.5 software for data analysis.Results A total of 3810 bacterial isolates and their antibacterial susceptibility data were collected.which included 2771(72.7%) Gram-negative bacterial strains and 1039(27.2%) Gram-positive bacterial strains. Resistant Staphylococcus aureus(MRSA) and methicillin resistant coagulase negative Staphylococcus aureus(MRCNS) detection rates were 31.2% and 84.4% respectively.No vancomycin and linezolid.intermediary or resistant strains were found.There were 3 strains of Enterococcus faecalis and 2 strains of Enterococcus faecium resistant to vancomycin.53.5%of Escherichia coli and 33.5% of Klebsiella pneumoniae isolates were the strains producing extended spectrum-β-lactamases(ESBLs).Pseudomonas aeruginosa to imipenem and meropenem resistance rates were13.8% and15.6% respectively.Acinetobacter to imipenem and meropenem resistance rates were 37.6% and 42.7% respectively. Bacterial resistance was increasing in East Sichuan.Enhanced antimicrobial resistance surveillance need to be strengthened for understanding the trend of antimicrobial resistance and providing the guidance for clinical choosing of antimicrobial agents.