Sichuan Provincial of antimicrobial Resistant Investigation Net 2011annual report:Bacterial drug resistance surveillance in North Sichuan

To investigate the resistance of clinical isolates of north Sichuan.Methods 3 hospitals in north sichuan were included in this program.Bacterial susceptibility test was performed according to an agreed protocol. Were analyzed according to Clinical and Laboratory Standards Institute(CLSI) 2010.The susceptibility data were processed with WHONET 5.5 software. A total of 5006 bacterial isolates and their antibacterial susceptibility data were collected.which included 4010(80.1%) Gram-negative bacterial strains and 996(19.9%) Gram-positive bacterial strains.Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus were the most common isolates.The incidences of meticillin-resistant S.aureus(MRSA) and meticillin-resistant coagulase negative Staphylococcus(MRCNS) were 18.2% and 87.0% respectively.No vancomycin and linezolid resistant Staphylococcus strains were found.There were 1.7% of Enterococcus faecalis and 2.6% of Enterococcus faecium resistant to vancomycin.No linezolid resistant Enterococcus were found.58.2%of Escherichia coli and 27.7% of Klebsiella pneumoniae isolates were the strains producing extended spectrum-β-lactamases(ESBLs).The resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa to imipenem were 43.2% and 18.1% respectively.The drug resistance rate of Acinetobacter baumannii was higher than that of Pseudomonas aeruginosa. Bacterial resistance was common in north Sichuan.Enhanced antimicrobial resistance surveillance need to be strengthened for understanding the trend of antimicrobial resistance and providing the guidance for clinical choosing of antimicrobial agents.