The Influence of Emulsifers on the Formation of Chitosan Microspheres

Chitosan microspheres were prepared by emulsion-dispersed chemical-crosslinking method and by using glutaradelhye as crosslinking agent, vacuum-pump oil and paraffin oil mixture as oil phase. The influence of emulsifers on the formation of chitosan microspheres was investigated. The results show that kinds and concentration of emulsifers affect the formation of chitosan microspheres. Under conditions of span-80 and magnesium stearate mixture with mass ration 3:1 as emulsifier, and the total concentration of emulsifier ranged from 10 g/L to 20 g/L, chitosan microspheres are gained with good spherical shape and diameters ranged from 1 m to 5 m.