2012•Dalian Gongye Daxue xuebaoRequires access
Preparation of chitosan microspheres
Qinghui Wu
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Abstract
Micron-sized chitosan microspheres were prepared by inverse suspension crosslinking method,using liquid paraffin as organic dispersion medium,and glutaraldehyde as crosslinking agent.The chitosan microspheres could be prepared in the conditions below: the concentration of chitosan solution was 4.5%,volume ratio of liquid paraffin and chitosan solution was 1∶1.5,the concentration of Span-80 in oil phase was 9.0 mg/mL,the volume ratio of glutaric aldehyde and chitosan solution was 1∶20,the stirring rate was greater than 800 r/min.The particle size of chitosan microspheres was 10 μm micron which have an adsorption capacity for some active substances.