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PREPARATION OF DRUG-LOADED CHITOSAN MICROSPHERES

Chuanli Zhou

Open publisher page 1 citations

Abstract

Chitosan microspheres loaded with 5-fluorouracil were prepared by crosslinking-emulsion method.The effect of the emulsifier,organic diffusion media,reaction time,glutaraldehyde amount,chitosan concentration and 5-fluorouracil concentration on microspheres property was investigated.The results showed that the optimum conditions for preparation were as follows:the ethyl benzoate as organic diffusion media,2ml Span-80,90min,2ml glutaraldehyde,1% chitosan and 1% 5-fluorouracil.At these conditions,the diameter,drug content and drug trapping efficiency of chitosan microspheres were 10～50μm,19.7% and 52.3%,respectively.

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What this paper is about

Chitosan microspheres loaded with 5-fluorouracil were prepared by crosslinking-emulsion method.The effect of the emulsifier,organic diffusion media,reaction time,glutaraldehyde amount,chitosan concentration and 5-fluorouracil concentration on microspheres property was investigated.The results showed that the optimum conditions for preparation were as follows:the ethyl benzoate as organic diffusion media,2ml Span-80,90min,2ml glutaraldehyde,1% chitosan and 1% 5-fluorouracil.At these conditions,the diameter,drug content and drug trapping efficiency of chitosan microspheres were 10～50μm,19.7% and 52.3%,respectively.

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Available abstract

Chitosan microspheres loaded with 5-fluorouracil were prepared by crosslinking-emulsion method.The effect of the emulsifier,organic diffusion media,reaction time,glutaraldehyde amount,chitosan concentration and 5-fluorouracil concentration on microspheres property was investigated.The results showed that the optimum conditions for preparation were as follows:the ethyl benzoate as organic diffusion media,2ml Span-80,90min,2ml glutaraldehyde,1% chitosan and 1% 5-fluorouracil.At these conditions,the diameter,drug content and drug trapping efficiency of chitosan microspheres were 10～50μm,19.7% and 52.3%,respectively.

Key concepts: Glutaraldehyde, Chitosan, Emulsion, Microsphere, Nuclear chemistry, Diffusion, Materials science, Chemistry

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