Treatment of early diabetic nephropathy with Shenkangning prescription

Objective To observe the clinical effect of early diabetic nephropathy( DN) treated by Shen-kangning prescription. Methods 120 DN patients were randomly divided into two groups. The cases in two groups were treated by conventional therapy. 60 cases in treatment group received Shenkangning prescription. 60 cases in con-trol group received Enalapril. The course was eight weeks in two groups. The changes of UAER,TNF-α,IGF-1, blood lipid and hemorheology before and after treatment were observed in two groups. Results The total effective rate in treatment group( 81. 67%) was superior to that in control group( 63. 33%,P 0. 05). UAER,TNF-α,IGF-1,TC,LDL-C,whole blood viscosity,plasma viscosity and erythrocyte aggregation index after treatment were de-creased in treatment group( P 0. 05,P 0. 01). There were significant differences between two groups on UAER, TNF-α,IGF-1,TC,LDL-C,whole blood viscosity,plasma viscosity and erythrocyte aggregation index( P 0. 05, P 0. 01). Conclusion Shenkangning prescription can decrease the levels of UARE,TNF-α and IGF-1 in pa-tients with early diabetic nephropathy,improve blood lipid and blood viscosity and effectively protect and treat early diabetic nephropathy.