A comparative study on the efficacy of buspirone combined with fluoxetine in the treatment of depression

Objective To explore the efficacy of buspirone combined with fluoxetine in the treatment of depression.Methods A total of 58 patients with depression were randomly devided into two groups,one group treated with buspirone combined with fluoxetine and the other with fluoxetine combined with placebo for 8 weeks of treatment.The efficacy and side effects were evaluated with HAMD and TESS.Results There were significant differences on decreased rates of HAMD between two groups in 2nd,4th,6th,8th weekend after treatment (P0.05).There were no significant differences on scores of TESS between two groups.Conclu-sion Buspirone combined with fluoxetine had better efficacy for treating depression with fewer side effects.