2014•Unpublished venueRequires access
The Adjustment Effect of 5-year-old planting ginseng on Hypothalamic-pituitary-gonadal axis function in Adult Rats
Zhang Hon
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Abstract
Objective To observe the effect of 5-year-old planting ginseng on hypothalamic- pituitary-gonadal axis function in normal adult rats, and to investigate the regulation of body's endocrine function through the edible of ginseng. Methods Normal adult Wistar rats were randomly divided into 10groups: control group, the low, medium, high-dose groups of original powder of 5-year-old planting ginseng(0.25, 0.5 and 1.0g crude drug / kg); the low, medium, high-dose groups of water extract from 5-year-old planting ginseng(0.25,0.5 and 1.0g crude drug / kg); the low, medium, high-dose group of ethanol extract from 5-year-old planting ginseng(0.25,0.5 and 1.0g crude drug / kg),fourteen rats for each group. The rats were administered orally three consecutive months, and observed the changes of hypothalamic-pituitary-gonadal axis function. Results Compared with the control group, serum FSH was lower in medium, high-dose groups of ginseng original powder,high-dose group of ginseng water extract and medium, high-dose groups of ethanol extract(P0.05 or P 0.01). Prostate viscera coefficient was higher in medium-dose group of ginseng original powder in normal adult male rats(P0.05). Testis and epididymis viscera coefficient was higher in low, high-dose groups of ginseng original powder in normal adult rats(P0.05). Each dose group of ginseng original powder, ginseng water extract and ethanol extract from ginseng had no significant effect on serum T, Cor. and NO of corpus cavernosum in normal adult male rats, serum E2, Cor. in normal adult female rats, serum LH and the viscera coefficient of penis, womb or ovary in normal adult rats(P 0.05). Conclusion Original powder, water extract and alcohol extract from ginseng have some adjustment effect on hypothalamic-pituitary-gonadal axis function in normal adult rats.