2014•Unpublished venueRequires access
The Effect of 5-year-old planting ginseng on Hypothalamic-pituitary-adrenal axis function in Adult Rats
Jiang Yi-chua
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Abstract
Objective To observe the effect of 5-year-old planting ginseng on hypothalamic-pituitary- adrenal axis function in normal adult rats, and to investigate the regulation of body's endocrine function through the edible of ginseng. Methods Normal adult Wistar rats were randomly divided into 10groups: control group, the low, medium, high-dose groups of original powder of 5-year-old planting ginseng(0.25,0.5 and 1.0g crude drug / kg); the low, medium, high-dose groups of water extract from5-year-old planting ginseng(0.25,0.5 and 1.0g crude drug / kg); the low, medium, high-dose group of ethanol extract from 5-year-old planting ginseng(0.25,0.5 and 1.0g crude drug / kg),fourteen rats for each group. The rats were administered orally three consecutive months, and observed the changes of hypothalamic-pituitary-adrenal axis function. Results Compared with the control group, plasma CRH was lower in medium, high-dose groups of ginseng original powder and high-dose group of ethanol extract from ginseng in normal adult rats(P0.05). Plasma ACTH was lower in high-dose group of ginseng original powder and medium, high-dose groups of ethanol extract from ginseng in normal adult rats(P0.05). Each dose group of ginseng original powder,ginseng water extract and ethanol extract from ginseng had no significant effect on serum GH in normal adult rats(P0.05). Each dose group of ginseng original powder,ginseng water extract and ethanol extract from ginseng had no significant effect on serum GH, weight or the viscera coefficient of adrenal and hypophysis in normal adult rats(P0.05). Conclusion Original powder and alcohol extract from ginseng have some adjustment effect on hypothalamic-pituitary-adrenal axis function in normal adult rats.