Compare the hypoglycemic effect of fresh ginseng and sun-dried ginseng on Type 2 Diabetes rats by high-fat diet and STZ-induced

OBJECTIVE To study the effects of Chinese herb of ginseng(Panax ginseng C. A. Meyer) in type 2diabetes mellitus(T2DM) rat model. METHODS 60 male Wistar rats were used in this study, and 8of them were taken as the normal controls, and the others were made into T2DM models with highfat diet(HFD) and then were injected with streptozotocin. After screening, the rat models were randomly divided into 4 group: model control group, insulin treatment group(0.5U/kg,ip), sun-dried ginseng group(RS-1: 600mg/kg, ig), fresh ginseng group(RS-2: 600mg/kg, ig). Then they were examined on fasting blood glucose,total cholesterol(TC), triglyceride(TG) detection after treatment for 8 weeks. RESULTS The result of fasting blood glucose test showed that the sun-dried ginseng group and the fresh ginseng group have hypoglycemic effect,fresh ginseng group performed significantly(p0.05), although the experimental data of total cholesterol, triglyceride detection were decreased, but did not change significantly, no statistically significant(p 0.05). CONCLUSION Studies showed that fresh ginseng and sun-dried ginseng improved glucose and lipids abnormality,fresh ginseng has a better effect on the treatment of type 2 diabetes model.