Retrospective analysis of prenatal screening on 35961 cases

Objective:To evaluate the clinic value of the double marker prenatal screening system for Down′s syndrome (DS),trisomy 18 and neural tube defects (NTD). Methods: DELFLA double marker reagents are used to test the concentrations of AFP and β-HCG in the serum of 35961 middle period pregnant women whose were pregnant for 14-21 weeks. With factors of children weeks,avoirdupois,age and so on,we evaluated the risk with risk evaluation software. Then compared the results whit type-B ultrasonic ,amniocentesis ,and results of the newborn′s examination. Results: Among the high risk cases of 36951,1856 (5.16%) cases indicate DS and 170 (0.47% ,1856/35961) cases suggest 18-Ⅲ. By amniocentesis,10 cases were diagnosed Down′s syndrome;5 cases were diagnosed 18-Ⅲ;259 (0.72% ,259/35961) examples with neural tube defect high risk were checked.61fetuses with neural tube defect were diagnosed. Conclusion: By the prenatal screening of blood serums AFP /β-hCG,it decreased the rate of birth defects. Prenatal screening has distinct economic and social benefit ,and it is a very effective technic means to carry out our country′s prepotency policy.