Retrospective analysis of prenatal screening on 46576 cases

Objective To evaluate the clinic value of the triple marker prenatal screening system for Down′s syndrome(DS)、trisomy 18 and neural tube defects(NTD),to evaluate the clinic value of the chromosome analysis of amniotic fluid cell for chromosome abnormity of fetus.Methods DELFLA triple marker reagents are used to test the concentrations of AFP、β-HCG and uE3 in the serum of 46 576 middle period pregnant women whose were pregnant for 14-21 weeks.With factors of children weeks,avoirdupois,age and so on,we evaluated the risk with risk evaluation software.Then compared the results whih type-B ultrasonic,amniocentesis,and results of the newborn's examination.Results Among the high risk cases of 46 576,5.06% cases indicate DS and 0.41% cases suggest 18-Ⅲ.By amniocentesis,12 cases were diagnosed Down,s syndrome;5 cases were diagnosed 18-Ⅲ;259 0.56% examples with neural tube defect high risk were checked.61 fetuses with neural tube defect were diagnosed.Conclusion Prenatal screening and prenatal diagnosis decreased the rate of birth defects.They have distinct economic and social benefit,they are very effective technical means to carry out our country's prepotency policy.